Product info: Arthritis
Arava (LEFLUNOMIDE) is used for reducing signs and symptoms of rheumatoid arthritis. It is also used to improve physical function and to prevent the development of structural damage to the joints.
Arava is a pyrimidine synthesis inhibitor. It is thought to work by blocking certain enzymes responsible for abnormal tissue development or growth.
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Special warnings about Arava
Arava is potentially damaging to the liver. Your doctor will test your liver function before starting Arava therapy. If you have significant liver disease, including hepatitis, you'll be unable to take Arava. If you develop liver problems while taking the drug, your dose will have to be reduced or eliminated.
Theoretically, Arava may interfere with your body's ability to fight off infection. The drug is therefore not recommended for people with cancer, bone marrow problems, severe infections, AIDS, or any other immune system problems. You should also avoid immunization with live vaccines while taking Arava.
Since there is a possibility that Arava could damage your liver or cause blood problems (such as a loss of white blood cells used to fight infection or a loss of cells that help your blood clot), it is essential that your doctor conducts a monthly blood test for the first 6 months of therapy, then every 6 to 8 weeks thereafter. If you are taking Arava and the cancer drug methotrexate together you may be even more susceptible to these problems. Your doctor will need to test your blood every month. Notify your doctor promptly if any signs of a blood problem appear. Warnings include easy bruising, frequent infections, unusual fatigue, and paleness.
Lung disease (including scarring of the lung) has been reported in patients taking Arava. Symptoms may include coughing, shortness of breath, and fever. Contact your doctor immediately if you develop any new or unusual symptoms.
Arava has been known to cause rare but serious skin reactions. If you develop a skin rash or eruption, stop taking Arava and contact your doctor. Arava can also reduce your blood cell count.
Your doctor will prescribe the drug cautiously if you have kidney problems, since poor kidney function can increase the amount of Arava in your system.
Arava does not appear to cause fetal harm when taken by the father prior to conception. Nevertheless, if you plan to father a child, your doctor will instruct you to stop taking Arava and will prescribe a regimen of cholestyramine to clear Arava from your system.
Possible food and drug interactions when taking Arava
If Arava is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Arava with the following:
Cholestyramine
Methotrexate
Nonsteroidal anti-inflammatory drugs such as ibuprofen, naproxen, and naproxen sodium
Rifampin
Tolbutamide
Special information if you are pregnant or breastfeeding
Do not take Arava while pregnant or breastfeeding. Taken during pregnancy, the drug can cause birth defects. And although it is not known whether Arava appears in breast milk, there is good reason to suspect that it will cause serious side effects in nursing infants.
Recommended dosage for Arava
ADULTS
The recommended starting dose is one 100-milligram tablet daily for the first 3 days. If you have an increased risk for blood disorders or liver problems, your doctor may choose to eliminate the 100-milligram starting dose to reduce the risk of serious side effects.
After the first 3 days, the doctor will reduce the dose to 20 milligrams a day. If side effects appear, the dose may be further decreased to 10 milligrams a day.
CHILDREN
Arava is not recommended for children less than 18 years old.
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Compare Arava with other medications for the treatment of:
Rheumatoid Arthritis
Click Here To More Information
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